ACUTE KIDNEY DISEASE

Acute kidney injury and chronic kidney disease.

Obesity and Kidney Disease

The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...

Yin and Yang: acute kidney injury and chronic kidney disease.

establish ultrasonographic criteria in patients who have unknown genotype and are at risk for ADPKD. Moreover, the results demonstrate that the diagnostic criteria currently in use for PKD1 may be inaccurate when applied to PKD2 because of higher risks for false-negative results yielding a reduced sensitivity for individuals aged 15 to 59. In summary, the authors propose new ultrasound diagnost...

Acute kidney injury: gateway to chronic kidney disease.

This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). The discussion focuses on subjects that recover from an episode of AKI, most of whom do not receive follow-up nephrology care. Many recent studies have shown a strong association between AKI and the risk of developing CKD. Preclinical models provide evidence...

Acute kidney injury induces hallmarks of polycystic kidney disease.

Acute kidney injury (AKI) and autosomal dominant polycystic kidney disease (ADPKD) are considered separate entities that both frequently cause renal failure. Since ADPKD appears to depend on a polycystin-1 (Pc1) or Pc2 dosage mechanism, we investigated whether slow progression of cystogenesis in two Pkd1 transgenic mouse models can be accelerated with moderate ischemia-reperfusion injury (IRI)....